Beilstein J. Org. Chem.2015,11, 2418–2434, doi:10.3762/bjoc.11.263
control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field.
Keywords: conjugate additions; electron-deficient alkenes; enantioselective catalysis; extendedMichaelacceptors; organometallic nucleophiles
various scenarios that can be expected with an α,β,γ,δ-unsaturated Michael acceptor.
Amongst the variety of transition-metal-based catalytic systems that have been evaluated in ACA reactions on extendedMichaelacceptors [1][3], copper-based systems have been the subject of tremendous interest, which
provided dramatic breakthroughs during the last two decades. This review aims to describe the early examples and recent advances in copper-catalyzed asymmetric conjugate additions of organometallic reagents to extendedMichaelacceptors. First, seminal reports dealing with the reactivity of extended
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Graphical Abstract
Figure 1:
Possible reaction pathways in conjugate additions of nucleophiles on extended Michael acceptors.